Next-gen hydrogel-based tools and specialty chemicalsDetails
Ectica Technologies is an innovative manufacturer and supplier of hydrogel-based tools and specialty chemicals for drug discovery, research, and manufacturing applications in the pharmaceutical, biotech and life sciences industries.
Ectica offers modern ready-to-use solutions to advance drug development and R&D programs such as the 3DProSeed™ hydrogel microtitre plate for advanced cell-based assays and phenotypic screenings, as well as OEM services and custom development and manufacturing of synthetic hydrogel formulations, bioconjugates including linkers for ADC, and recombinant enzymes.
Advancing drug discovery with the hydrogel cell culture platform
Translation of in vitro data into in vivo models is a significant challenge in drug discovery, where drug candidates often fail at different stages of preclinical and clinical studies. Ectica Technologies has developed an innovative solution to help overcome these hurdles – the 3DProSeed™ hydrogel microtitre plate.
With this ready-to-use hydrogel-based cell culture platform for drug screening applications, it is possible to culture cells in an artificial 3D environment emulating in vivo conditions better than with conventional glass or polystyrene substrates, while maintaining comparable workflows. The platform offers the highest level of compatibility to automation because the hydrogels are pre-casted in imaging plates.
The opportunity to establish advanced cell-based assays and profile drug candidates in the early study stages can significantly increase a drug candidate’s chance to succeed in the clinical stages.
New-gen tools for advanced cell-based assays and phenotypic screenings
Ectica’s patented 3DProSeed™ technology combines the biological relevance of hydrogel-based cultures with high workflow integration levels in drug discovery.
3DProSeed hydrogels are made of fully synthetic – animal free – materials based on state-of-the-art poly(ethylene glycol) (PEG)-bioconjugates and feature a patented engineered hydrogel surface that supports active penetration inside the hydrogel of the cells deposited on top of it. With 3DProSeed hydrogels it is possible to develop advanced 3D co-culture systems embedded in hydrogels without the need for the user to take any hydrogel assembly steps, making the process fast and convenient. 3DProSeed thus brings together advanced hydrogel-based cultures and the workflow and screening compatibility of standard polystyrene cultureware.
Application examples include 3D neuronal and vascular networks, matrix-embedded tumouroids and other systems. Ectica Technologies manufactures and supplies the 3DProSeed™ hydrogel microtitre plate line for drug discovery and research in the therapeutic areas of oncology, immuno-oncology and neurosciences.
Assay complexity contributes to development time and cell-based assays are notoriously more complex than biochemical assays. Maximising time in the laboratory is especially important to ensure researchers accomplish quality results.
With this in mind, the 3DProSeed design format consists of an imaging glass-bottom microtitre plate containing pre-assembled, fully synthetic hydrogels that are delivered to the customer’s hydrated, ready-for-cell seeding.
In addition, Ectica Technologies engages in research collaborations with industrial partners interested in the integration of advanced hydrogel-based assays in their capabilities.
OEM – Private Label hydrogels solutions
Ectica Technologies also offers original equipment manufacturing (OEM) – Private Label hydrogels solutions. To answer specific client requirements, Ectica’s OEM solutions include an extensive range of products and customisation capabilities in terms of hydrogel chemistry, product format, usage and branding.
Specialty chemicals for drug formulations, bioresearch and biomanufacturing
Ectica Technologies provides expertise, custom development and manufacturing of synthetic hydrogel formulations, bioconjugates including antibody-drug conjugate linkers and recombinant enzymes.
Ectica Technologies specialty chemicals focus is on:
- Fully synthetic hydrogel formulations with custom biochemical and physical characteristics for specific applications in pharma, bioresearch and biomanufacturing, including cell therapy.
- Custom bio-conjugation of polyethylene glycol and other polymers with peptides and protein fragments for various applications, including linkers for antibody-drug conjugation.
- Highest class of recombinant enzymes for targeted bioconjugation purposes.
The company’s development and manufacturing activities start at lab-scale pilot batches and small-scale pilot batch production. Its activities are conducted in Zurich, Switzerland, in International Standards Organisation (ISO) 5 to good manufacturing practice (GMP-B) certified cleanroom environments.
Unique manufacturing process capabilities
Ectica Technologies has exceptional expertise and a special set of patented manufacturing processes covering:
- High-spatial-resolution soft coatings of multi-electrode arrays (MEA) and other semi-conducting substrates. Ideal for applications where batch processing is needed, additive manufacturing is not sufficiently fast or precise, or coating of substrates in a liquid environment is required.
- Advanced demoulding processes specifically designed for soft hydrogel materials. Ideal for applications in which the hydrogel material risks of breaking during the demoulding procedure.
About Ectica Technologies
Headquartered in Zurich, Switzerland, Ectica Technologies is a young and vibrant company developing and producing ground-breaking solutions for drug development, R&D and manufacturing in the pharmaceutical, biopharmaceutical and life science space. Ectica products and services have received special recognition and are used by world-leading pharmaceutical and life sciences organisations including Merck KGaA.ProductsEctica Technologies provides modern proprietary hydrogel deposition and demoulding manufacturing processes. Innovative hydrogel deposition and demoulding manufacturing capabilities Through its …
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