Ectica Technologies

Ectica Technologies is an innovative manufacturer and supplier of hydrogel-based tools and specialty chemicals for drug discovery, research, and manufacturing applications in the pharmaceutical, biotech and life sciences industries.

Ectica offers modern ready-to-use solutions to advance drug development and R&D programs such as the 3DProSeed™ hydrogel microtitre plate for advanced cell-based assays and phenotypic screenings, as well as OEM services and custom development and manufacturing of synthetic hydrogel formulations, bioconjugates including linkers for ADC, and recombinant enzymes.

Advancing drug discovery with the hydrogel cell culture platform 

Translation of in vitro data into in vivo models is a significant challenge in drug discovery, where drug candidates often fail at different stages of preclinical and clinical studies. Ectica Technologies has developed an innovative solution to help overcome these hurdles – the 3DProSeed™ hydrogel microtitre plate.

With this ready-to-use hydrogel-based cell culture platform for drug screening applications, it is possible to culture cells in an artificial 3D environment emulating in vivo conditions better than with conventional glass or polystyrene substrates, while maintaining comparable workflows. The platform offers the highest level of compatibility to automation because the hydrogels are pre-casted in imaging plates.

The opportunity to establish advanced cell-based assays and profile drug candidates in the early study stages can significantly increase a drug candidate’s chance to succeed in the clinical stages.

New-gen tools for advanced cell-based assays and phenotypic screenings

Ectica’s patented 3DProSeed™ technology combines the biological relevance of hydrogel-based cultures with high workflow integration levels in drug discovery.

3DProSeed hydrogels are made of fully synthetic – animal free – materials based on state-of-the-art poly(ethylene glycol) (PEG)-bioconjugates and feature a patented engineered hydrogel surface that supports active penetration inside the hydrogel of the cells deposited on top of it. With 3DProSeed hydrogels it is possible to develop advanced 3D co-culture systems embedded in hydrogels without the need for the user to take any hydrogel assembly steps, making the process fast and convenient. 3DProSeed thus brings together advanced hydrogel-based cultures and the workflow and screening compatibility of standard polystyrene cultureware.

Application examples include 3D neuronal and vascular networks, matrix-embedded tumouroids and other systems. Ectica Technologies manufactures and supplies the 3DProSeed™ hydrogel microtitre plate line for drug discovery and research in the therapeutic areas of oncology, immuno-oncology and neurosciences.

Ready-for-cell seeding 

Assay complexity contributes to development time and cell-based assays are notoriously more complex than biochemical assays. Maximising time in the laboratory is especially important to ensure researchers accomplish quality results.

With this in mind, the 3DProSeed design format consists of an imaging glass-bottom microtitre plate containing pre-assembled, fully synthetic hydrogels that are delivered to the customer’s hydrated, ready-for-cell seeding.

In addition, Ectica Technologies engages in research collaborations with industrial partners interested in the integration of advanced hydrogel-based assays in their capabilities.

Pre-developed Stromal Models

Ectica Technologies recently launched its novel 3DProSeed ® StromaLine ® – a game-changing collection of pre-developed and well characterized stromal models, designed to advance and simplify tumor-stroma interaction studies. Utilising the StromaLine ® by Ectica, researchers can perform anti-cancer drug screenings in the presence of the stromal compartment with minimal adaptation efforts.

Ectica Technologies provides expertise, custom development and manufacturing of synthetic hydrogel formulations, bioconjugates including antibody-drug conjugate linkers and recombinant enzymes.

Ectica Technologies specialty chemicals focus is on:

• Fully synthetic hydrogel formulations with custom biochemical and physical characteristics for specific applications in pharma, bioresearch and biomanufacturing, including cell therapy.
• Custom bio-conjugation of polyethylene glycol and other polymers with peptides and protein fragments for various applications, including linkers for antibody-drug conjugation.
• Highest class of recombinant enzymes for targeted bioconjugation purposes.

Ectica Technologies AG

Raeffelstrasse 24
8045 Zurich

Switzerland

info@ectica-technologies.com

www.ectica-technologies.com

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