Next-gen hydrogel-based tools by Ectica Technologies
Ectica’s breakthrough 3DProSeed StromaLine with pre-developed and characterized pulmonary and pancreatic tumor stromal models
Discover the next generation 3DProSeed StromaLine Lung and Pancreas Tumor Stroma – pre-developed, assay-ready and highly characterized pulmonary and pancreatic tumor stromal models made of patient-derived cancer associated fibroblasts (CAFs), excellent for tumor-stroma interaction research.
The significance of the tumor microenvironment for cancer growth, progression, and metastasis is well recognized. Stromal cells and their extracellular matrix (ECM), specifically, are major factors determining cancer pathophysiology. For instance, in lung adenocarcinoma, the stroma component of the cancer to a great extent establishes the clinical manifestation of the disease and bears significant prognostic information. Cancer-associated fibroblasts (CAF) in the stroma can modify cancer epithelial cell phenotype by direct cell-cell contacts, the secretion of soluble factors, or the modification of the ECM. Such crosstalk between CAF and epithelial cancer cells has been implicated in the development of therapy resistance. In this sense, creating physiologically relevant ex vivo models to study CAF-cancer cell interactions holds great potential for cancer therapy.
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