High-precision Laser Microdissection System
The groundbreaking CellCut high-precision laser microdissection system enables the dissection of tissue areas, single cells and subcellular structures with accuracy that is unmatched on the market.
Developed by Molecular Machines & Industries (MMI), the CellCut high-precision laser microdissection system facilitates clean and precise dissection of almost any type of sample, from entire areas of tissue down to single cells and even subcellular structures as small as 5 µm.
High-precision Laser Microdissection System
Harnessing MMI’s cutting-edge laser technology, the CellCut laser microdissection system facilitates the cleanest and the most precise dissection of nearly any sample type. Whether handling live or fixed cells, cell clusters, single cells or subcellular components from numerous tissue types such as fresh frozen, FFPE material, archived slides, cytospins and smears, the ultra-precise CellCut system guarantees the highest sample integrity by facilitating accurate and contamination-free dissection and secure collection.
By enabling researchers to dissect live cells without removing culture media, the CellCut laser microdissection system ensures the highest cell integrity for re-cultivation, cloning, and single-cell analysis. It also handles large areas beyond the field of vision providing a more indicative snapshot of the biological context.
Unparalleled Laser Microdissection Precision Guarantees the Highest Sample Integrity
The MMI CellCut sets a new standard for microdissection precision, delivering unparalleled accuracy in the market. MMI’s unique high-precision laser microdissection technology ensures the thinnest and cleanest cut, achieving a width of up to 0.3 micrometers (µm).
This level of precision is instrumental in preventing sample degradation and safeguarding the surrounding area to preserve critical biological information, such as RNA, DNA, and proteins. The preservation of sample quality enhances downstream applications, leading to more reproducible results.
Seamless Integration and Advanced Flexibility for Precision Microdissection
MMI’s micromanipulation technology is defined by its excellent quality, efficiency and modularity to satisfy the specific needs of individual research projects. The CellCut laser capture microdissection (LCM) system provides advanced flexibility and seamlessly integrates with all MMI single-cell solutions, including the MMI CellScan digital whole slide scanner, the MMI CellEctor cell picker and the MMI CellManipulator optical tweezers system. The laser capture microdissection is also compatible with all objective lenses and imaging modes and almost all inverted microscopes.
Harnessing the Power of AI-driven Automated Tissue Analysis Software
The CellCut’s ultra-precise microdissection performance is boosted with the optional addition of the sophisticated CellDetector AI-driven automated tissue analysis software. This advanced artificial intelligence-based tissue analysis software enables easy and intuitive detection and accurate counting of Regions of Interest (ROI), ranging from whole tissue areas down to single cells and subcellular structures.
Laser Microdissection Applications
The MMI CellCut system’s exceptionally gentle cutting and contamination-free isolation make it a powerful tool for genomics (DNA), transcriptomics (mRNA, miRNA), proteomics, lipidomics, metabolomics research and even next-generation sequencing (NGS). The high-precision laser microdissection system is also an ideal tool for live cell culture, cloning and re-cultivation, manipulation or downstream analysis.
Researchers in neurology, cancer research, immunology, and other therapeutic fields rely on this method for a wide range of applications in R&D and drug discovery. In addition, the MMI CellScan digital whole slide scanner can be integrated into the MMI CellCut Laser Microdissection platform, to seamlessly bridge digital and molecular pathology and extract maximum information from a single tissue section.
Accelerating High-precision Cancer Research
MMI’s advanced laser microdissection technology empowers high-precision cancer research. Utilising the MMI CellCut researchers can reliably isolate single cells from tissue sections, allowing extraction of RNA for transcriptomics and sequencing.
Harnessing the power of the CellCut for precise isolation of specific tumor cell populations based on morphology, researchers can extract malignant clones within heterogeneous tumors and establish physiological expression levels. By analysing gene expression, the CellCut aids in classifying cancer tumors and identifying potential biomarkers. This information is crucial for the development of novel and effective therapeutic strategies.
Excision of Single Tumor Cells in Cancer Diagnosis and Therapy
Characterising tumor mutational heterogeneity is crucial to identify the most effective therapy for cancer patients. MMI’s high-precision laser microdissection system enables the excision of single tumor cells for mutational burden analysis. This approach is applicable across any cancer type with tissue heterogeneity, such as breast cancer, lung cancer, or prostate cancer. Studies suggest that tumor heterogeneity is reflected in Circulating Tumor Cells (CTCs) offering new insights into therapy response and relapse mechanisms through liquid biopsies. To comprehensively study cancer heterogeneity, the MMI CellCut can be expanded with the MMI cell picker CellEctor system into one microscopy platform. The MMI CellEctor instrument allows clinicians to select individual CTCs from patient samples and analyse their genomic integrity.
Features:
- Ultra-precise cut of up to 0.3 (µm)
- Cut almost any sample type
- Cut live cells
- Gentle and contamination-free sample collection
- Handles large areas beyond the field of vision
- Compatible with almost all inverted microscopes and objective lenses
- Compatible with all MMI systems
The MMI CellCut system is developed by Molecular Machines & Industries (MMI), a team with over 20 years of experience in laser microdissection. For more information contact MMI’s experts today or request a quote:
