Molecular Machines & Industries

The MMI CellCut laser microdissection system allows clean and precise dissection of almost any type of sample, including live or fixed cells, cell clusters, single cells or subcellular components from numerous tissue types such as fresh frozen, paraffin-embedded formalin fixed (FFPE), archived slides, cytospins and smears. This laser microdissection system guarantees highest sample integrity by facilitating contamination and error-free dissection and collection.

The MMI CellCut boasts the most precise cutting performance on the market, which implies the thinnest and cleanest cut, protecting the surrounding area and biological information. The CellCut laser capture microdissection (LCM) system offers exceptional flexibility and is compatible with all MMI single cell solutions, and almost all inverted microscopes objective lenses and imaging modes. The integration of the CellDetector AI-based tissue analysis with MMI’s CellCut enables users to accurately extract their region of interest (cells/tissue) using laser capture microdissection.

Digital 5D Whole Slide Imaging System

The MMI CellScan is a whole slide scanner that captures full-resolution digital slides in 5D, including time-lapse, z-stack, XY scan, and multi-color fluorescence imaging. The MMI CellScan is compatible with a wide range of research microscopes and imaging modes, and can be combined with the MMI CellCut for laser microdissection. The MMI CellScan enables quantitative and qualitative assessment of tissue morphology and pathology, and integration of the data with other omics platforms. This whole slide scanner is ideal for applications, such as spatial transcriptomics, tumor heterogeneity, liquid biopsy, rare and single cells isolation, digital pathology, and molecular pathology.

With the addition of the fully compatible CellDetector software researchers have the option to create digital slides and identify regions of interest from live images.

Cell Picker System

The MMI CellEctor is a cell picker that enables selective isolation of rare and single cells in suspensions, such as circulating tumour cells and stem cells,as well as adherent cells with the innovative shake mode. The MMI CellEctor ensures the highest cell integrity and growth rates by gentle cell transfer and collection. The cell picker system is compatible with various slide-based platforms and microscopes, providing the most flexible cell picking performance on the market.

Utilising the MMI CellEctor in conjunction with the MMI CellDetector software enables automated cell detection and cell picking based on colour, morphology, and relative size allowing user-defined liquid handling for collection and deposition of single cells. The system is ideal for various applications in pathology and oncology.

Optical Tweezers System for Ultra-precise Manipulation 

The MMI CellManipulator is an optical tweezers system ensuring ultra-precise manipulation with the finest force measurements of single cells and molecules in sub-pN resolution. The MMI CellManipulator is compatible with almost all inverted or upright research microscopes and can be combined with fluorescence, TIRF, confocal microscopy, and other customised adaptations. This optical tweezers system enables comfortable, contact-free, and real-time control of up to 20 microscopic particles, living suspended cells, or subcellular organisms. The MMI CellManipulator is ideal for applications, such as cell fusions, cell-to-cell interactions, intracellular manipulations, molecular motors, optical trapping, and biosensor assays.

Automated Tissue Analysis Software

The MMI CellDetector is an AI-driven software that automatically identifies and quantifies cells across diverse tissue samples. The CellDetector is an integral part of MMI’s suite of solutions and seamlessly integrates with all MMI systems.

The MMI CellDetector software is powered by sophisticated algorithms to facilitate accurate automated tissue analysis. Notably, this advanced software excels in analysing microscopic images and provides precise detection even in complex images under challenging conditions with varying light and staining.

By harnessing the capabilities of CellDetector, digital pathology takes a significant leap forward. Employing AI, it precisely identifies tumour regions in immunohistochemistry (IHC) or fluorescently stained samples. This automated approach eliminates the laborious task of manual annotations, ensuring accurate analysis of multiple markers and stains.