Machine Learning-Powered Analysis of Organoid-Immune Cell Co-Cultures

Advancing Beyond 2D Models

A TissueGnostics White Paper

While 2D cell cultures have been a staple in research, their inability to replicate tissue complexity limits their utility. 3D organoids, with their self-organizing, organ-mimicking structures, provide a superior model for studying immune interactions, drug development, and precision medicine.

Overcoming Key Challenges in 3D Cell culture Analysis

Co-culturing organoids with immune or stromal cells enhances physiological relevance but introduces imaging hurdles:

• Variable focal depths in extracellular matrix gels
• Heterogeneous organoid morphology
• Immune cell clusters obscuring detection

Traditional tools (e.g., Incucyte®, OrganoSeg) lack precision in this context, leaving researchers without reliable high-throughput solutions—until now.

The Organoid App Solution

Powered by machine learning, the StrataQuest Organoid App delivers:

• Automated organoid detection (count, size, density) in immune co-cultures
• High accuracy matching human-eye precision
• Time-lapse & endpoint analysis via TissueFAXS® PLUS microscopy
• Cross-platform compatibility (brightfield/fluorescence, multiple file formats)

Unlock the full potential of organoid-immune cell studies—
Download the full case study to explore how StrataQuest can transform your research.

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