Nucleosides, Nucleotides & Nucleic Acids Toolbox – Free E-Book – Biosynth

Nucleosides, Nucleotides & Nucleic Acids Toolbox

A Biosynth .pdf E-Book

Part 1 – Nucleosides and Nucleotides Chemistry, Structures, Modifications Analysis, Applications

Nucleosides and nucleotides, along with their analogs, as well as oligomers and polymers derived from them, play a pivotal role in the realm of living organisms. This handbook has been crafted to serve as a fundamental introduction and concise summary for individuals intrigued by this category of molecules. It constitutes the initial volume in a two-part series dedicated to nucleotides, nucleosides, and nucleic acids. In this first handbook, we delve into their structure, historical significance, and chemical properties, along with highlighting some of their significant applications in the fields of life sciences and medicine. Rather than striving for absolute comprehensiveness, these books are curated to gather essential concepts, narratives, advancements, and practical uses within both commercial and research contexts.

This handbook places its emphasis on exploring the aspects related to structure, analysis, and synthesis. Meanwhile, the second handbook, the counterpart to this volume, delves into the narrative of their oligomers, including the pivotal DNA and RNA molecules, which serve as the carriers of genetic information. Together, these two handbooks form a complementary pair that presents a comprehensive account, spanning from the basic building blocks to intricate oligomeric structures.

Table of Contents:

  • Introduction and Scope
  • About the Author
  • About Biosynth
  • Nucleosides and Nucleotides – Structures and Nomenclature
  • Nucleosides and Nucleotides – Chemistry and Analytics
    – Milestones in Nucleoside Chemistry
    – N–Glycosylation of Ribose – Towards Ribo- and Deoxyribonucleosides
    – Spectroscopy and Chromatography
  • Nucleoside Modifications in Nature and Medicine
    – Natural Modifications
    – Modified Nucleosides as Drugs
    – Antivirals
    – Anticancer Drugs
    – Antibiotics/Antifungals
  • Nucleotides – Phosphoric Acid Esters of Nucleosides
    – Nucleoside 5’-Mono-, Di- and Triphosphates
    – Nucleotides in Energy Metabolism
    – Sugar Nucleotides
    – Nucleotides as (Pro-)Drugs
  • Summary and Conclusions
  • References

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