Enzyme Engineering and ManufacturingDetails
EUCODIS Bioscience is a leading Austrian enzyme engineering and manufacturing company operating globally to serve customers in the pharmaceutical, biotechnology, cosmetic and diagnostics industries. Certified under ISO 9001:2015, EUCODIS Bioscience is an expert in delivering the highest quality enzymes meeting both customer and regulatory requirements.
High-performance enzyme engineering and manufacturing
EUCODIS Bioscience has an established history of providing high-performance enzyme solutions with a portfolio of more than 50 enzymes that include advanced lipases, beta-lactamases, peroxidases, phospholipases and other enzymes.
Working closely with its customers to gain a deep understanding of their needs and meet their individual biocatalyst requirements, EUCODIS is an application-driven provider of novel and personalized enzyme solutions designed to perform in challenging industrial applications.
Custom enzyme production for pharmaceutical applications
Through its long-standing expertise in enzyme engineering and manufacturing for pharmaceutical and biotechnological applications and its innovative state-of-the-art enzyme engineering technology toolbox including e.g., the patented in vivo recombination system, EUCODIS Bioscience has the ability to design and select target enzymes displaying activity, substrate selectivity or stability profiles as per its client’s precise requirements.
Together with advanced high-throughput screening capabilities and assay platforms that accelerate workflow, the company can provide optimized enzymes with the desired properties on time and on budget.
Identification and screening of novel enzymes for target reactions
Identification and screening of novel enzymes for target reactions can be based on the selection of candidate enzymes from the EUCODIS collection and through library and database screening.
To discover the desired enzyme parameters EUCODIS Bioscience begins by developing high-throughput screening assays for custom substrates and reactions. The specific parameters such as activity, selectivity and reaction kinetics can be validated using HPLC-MS or GC-MS analytics for lead enzyme candidates.
Protein and enzyme analysis
All enzymes and proteins produced by EUCODIS are fully analysed and characterized using advanced analytical methods carried out under the ISO9001 quality management system. These include, protein analytics, activity analyses with different substrates, purity and contaminant analysis, mass spectrometry and differential scanning calorimetry.
Contract manufacturing of recombinant proteins and enzymes
EUCODIS Bioscience has contract manufacturing capabilities for recombinant protein and enzyme production that cover the whole spectrum of custom protein & enzyme services, including:
- Protein & enzyme engineering
- Strain & bioprocess development
- Fermentation in prokaryotic and eukaryotic host expression systems
- DSP & protein purification
- Routine industrial protein manufacturing
Specialised in establishing optimized bioprocesses for the scale-up and manufacture of recombinant proteins certified under ISO 9001:2015, EUCODIS Bioscience can achieve the highest yields, stability and purity that are reproducible, scalable and meet international safety and quality standards.
Innovative enzymatic linker technology
Designed by EUCODIS Bioscience, the novel proprietary enzymatic linker technology CTATTM covalently attaches a payload molecule, such as a drug molecule or a dye for diagnostics, to a recombinant antibody, antibody fragment, or protein through a site-specific enzymatic reaction.
Thanks to this direct conjugation approach the antigen binding site or antibody structure are not altered, producing antibody-drug conjugates (ADC’s) with a defined drug-antibody-ratio (DAR) which have shown superior efficacy in first studies. EUCODIS provides its patented CTATTM technology for licensing on a target basis or as a whole.
About EUCODIS Bioscience
Founded in 2007, EUCODIS Bioscience has a wealth of experience in providing high-performance enzyme solutions for applications in pharma, biotech and diagnostics. The company’s headquarters and main laboratories are located at the Campus Vienna Biocenter, the largest Biotech and University cluster in Austria.
Together with its wide collaboration and partner network around the world, EUCODIS can deliver an exceptional product portfolio and comprehensive solutions to its customers in all areas of enzyme and bioprocess development.ProductsDownloadsNovel lipases of microbial origin selected and engineered for best performance. A EUCODIS Bioscience Case Study EUCODIS Bioscience offers a …
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Read MoreFollowing the enormous success of Candida antarctica lipase B (CalB) variants introduced in 2017, EUCODIS Bioscience has now added novel …
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