Automated sample preparation for tablets

Fully automated sample preparation for tablet content determination

A Methrom Case Study

The production of pharmaceutical tablets requires proving that the active ingredient indicated on the packaging is valid for each and every tablet of a batch.

Titration and ion chromatography are some of the analytical techniques used for the highly accurate quantitation of the ingredients. However, these analytical techniques are only as reliable as the sample preparation preceding them. Depending on the shape, coating, filling components used and concentration of the pharmaceutical ingredient, different sample preparation steps have to be carried out before the analysis proper.

Through the use of an automated system that performs every sample preparation in exactly the same way, the content of the active ingredient in a single tablet as well as the product conformity of the whole batch can be determined with just one automation system. Automation can not only improve reproducibility and accuracy but also increase throughput as well as lab safety.

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