Ribonuclease A – (RNase A ≥70U/mg and ≥100U/mg)

GERBU offers high-quality Ribonuclease A (RNase A) in ≥70U/mg and ≥100U/mg as a freeze-dried powder or as a solution upon request.

GERBU’s Bovine Pancreatic Ribonuclease A is salt-free and purified by chromatography. This RNase A is ideally suitable for applications including diagnostic assay manufacturing, plasmid purification, isolation of high-quality genomic DNA, RNA sequencing, and removal of RNA.

Ribonuclease A (RNase A)

Manufactured by GERBU Biotechnik, this Ribonuclease A (RNase A) is salt-free and purified by chromatography to ensure exceptional quality and reliability. It is available with high enzymatic activity of ≥100U/mg and 70U/mg, guaranteeing efficient RNA degradation.

The GERBU RNase A is stable at high temperatures and low pH and is compatible with most buffers and reagents, allowing for a wide range of experimental conditions, and providing greater flexibility and ease of use.

Ribonuclease A (RNase A) Applications

Bovine pancreatic ribonuclease A (RNase A) is an enzyme that facilitates the hydrolysis of phosphodiester bonds within RNA molecules by cleaving P–O5′ bonds. RNase A plays a crucial role in the degradation and processing of RNA.

RNase A finds extensive utility in the realm of molecular biology, diagnostics, and pharma where it serves a multitude of applications. Its versatility makes it a go-to enzyme for several key applications, including the purification of plasmids, the isolation of high-quality genomic DNA, the elimination of residual RNA from DNA samples, and the examination of RNA structure and function.

A well-studied enzyme for working with RNA molecules

RNase A is a type of enzyme that can break down RNA molecules into smaller fragments. Removing RNA from DNA and protein samples can help to purify DNA or protein from unwanted RNA contamination, which can interfere with some experiments or applications. Analyzing RNA sequences and structures can help to understand how RNA molecules function and interact with other molecules. RNase A can cut RNA at specific sites or protect RNA from being cut by other RNases, depending on the experimental conditions.

Designing new drugs based on RNase A structure and function can help to find new ways to inhibit or modulate RNase A activity, which can have therapeutic implications for some diseases.

RNase A is a well-studied enzyme that has a known structure and catalytic mechanism. It can be easily used in different buffers and reagents. It is a valuable tool for researchers who work with RNA molecules or need to remove them from their samples.

RNase A for diagnostic assay manufacturing

Before performing RT-qPCR, a sample needs to be processed to remove any unwanted RNA that could interfere with the test. This is where RNase A is commonly used. RNase A can degrade any RNA that is not protected by a reverse transcriptase enzyme, which converts RNA into DNA. With the inclusion of RNase A in the sample subsequent to reverse transcription, solely the viral DNA remains unaltered and primed for amplification.

RNase A can also be used in other types of diagnostic tests, such as isothermal nucleic acid amplification assays and CRISPR-based methods. These tests also rely on converting RNA into DNA and amplifying it, although they use different enzymes and mechanisms. RNase A may be utilised to improve the specificity and sensitivity of these tests by removing any residual RNA from the sample.

RNase A is seen as a particularly valuable enzyme for SARS-CoV-2 detection because it can help to reduce false negative and false positive results, which are crucial for accurate diagnosis and public health interventions.

If you are working on these types of applications and need high-quality Ribonuclease A (RNase A), contact GERBU’s experts today for more information.

ribonuclease A (RNase A)
GERBU offers high-quality Ribonuclease A (RNase A) 100u/mg and 70u/mg available in lyophilized powder form or as a solution upon request


  • Ribonuclease A (RNase A)
  • Salt-free and purified by chromatography
  • ≥70U/mg
  • ≥100U/mg
  • White freeze-dried powder
  • Available as a solution upon request
  • 3‘-pyrimidino-oligonucleotidohydrolase Ribonucleate 3‘-pyrimidino-oligonucleotidohydrolase Ribonuclease I
  • CAS Nr.: [9001-99-4]

For use in laboratory and production. Not for human or animal use. For professional users only.

For more information and orders please contact GERBU today: