GERBU manufactures high-quality NADH – β-Nicotinamide adenine dinucleotide, a reducing agent for biochemical assays.
NADH reagents are utilised in enzyme cycling assays to boost the detection of activity of biologically relevant enzymes or metabolites present in low concentrations.
GERBU’s reduced (NADH) – β-Nicotinamide adenine dinucleotide is available in 1g, 5g, and 25g package sizes.
Reduced (NADH) – β-Nicotinamide adenine dinucleotide
NADH is a reducing agent used for biochemical assays. Functions as a coenzyme for many oxidoreductases. NADH reagents are utilised in enzyme cycling assays to boost the detection of activity of biologically relevant enzymes or metabolites present in low concentrations.
In metabolism, Nicotinamide Adenine Dinucleotide (NAD) is involved in redox reactions, carrying electrons from one reaction to another. It is found in two forms in cells, as an oxidizing agent NAD+ and as a reducing agent NADH. The oxidizing agent NAD+ accepts electrons from other molecules and becomes reduced, creating NADH, which can then be used as a reducing agent to donate electrons. It is a substrate for the poly (ADP-ribose) polymerases (PARPs) nuclear DNA damage sensors during the recognition and repair of single-strand DNA breaks.
NAD+/NADH-dependent sirtuins play important roles in stress responses during events involving energy metabolism, with implications in cancer biology, diabetes, and neurodegenerative diseases.
Detection of enzyme targets for drug discovery
NADH is a facilitator of numerous biological reactions. It works as a regenerating electron donor in catabolic processes including glycolysis, β-oxidation, and the citric acid cycle ( also known as the Krebs cycle or TCA cycle). NADH also takes part in cell signaling events. An example is, as a substrate for the poly (ADP-ribose) polymerases (PARPs) nuclear DNA damage sensors during the recognition and repair of single-strand DNA breaks.
In R&D, NADH reagents can help increase the detection of enzyme targets for drug discovery or metabolites in enzyme cycling assays.
- Reducing agent
- β-Nicotinamide Adenine Dinucleotide (Reduced NADH)
- ≥93% purity
- Available in 1g, 5g, and 25g pack sizes
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