Recombinant HLA Proteins

imusyn offers an unmatched portfolio of top-tier recombinant HLA class I and class II proteins, produced as truncated, soluble antigens in mammalian cell culture. HLA proteins are essential for studying immune recognition, T cell antigen presentation, tissue compatibility, peptide-based vaccines and immunopeptidomics.

Recombinant HLA Class I and II Proteins

imusyn’s high-quality recombinant HLA proteins are pivotal for immune recognition, antigen presentation, tissue compatibility, and personalised medicine.

HLA class I forms complexes with β2-microglobulin, while HLA class II adopts zipper-stabilised heterodimers. imusyn implements a stringent quality control regimen that encompasses purity evaluation and functional validation via specific antisera, ensuring the best quality and effectiveness of the products. With imusyn’s high-quality HLA molecules, researchers can have complete confidence in exploring the immunological landscape.

HLA Class I Molecules

HLA Class I proteins are responsible for presenting intracellular antigens to CD8 T cells and play a pivotal role in immune recognition. imusyn’s comprehensive portfolio includes close to 100 recombinant HLA class I proteins.

By studying HLA class I, researchers can gain key insights into the body’s immune response against infections, tumors, and other cellular abnormalities. In transplantation, HLA class I compatibility is crucial to prevent graft rejection.

Have a look at some of the most popular HLA class I proteins…

HLA-A*02:01  HLA-A*11:01  HLA-A*23:01  HLA-A*24:02

HLA-B*07:02  HLA-B*08:01  HLA-B*18:01  HLA-B*27:05  HLA-B*35:01

HLA-C*07:01  HLA-C*07:02  HLA-C*08:01

…or discover imusyn’s extensive HLA class I portfolio:

HLA-B*07:02 Sample Application: HLA sandwich ELISA standard curve with imusyn’s recombinant HLA-B*07:02 antigen (REF B07:02M) using imusyn’s monoclonal antibodies W6/32 and BBM.1.

HLA Class II Proteins

HLA Class II proteins are essential for antigen presentation to CD4+ T cells. Understanding HLA class II interactions helps unravel the complexities of adaptive immunity. imusyn offers an array of over 70 recombinant HLA class II proteins, each with diverse α- and β-chain combinations, thereby ensuring a comprehensive range of options for cutting-edge research.

Have a look at some of the most popular HLA class II proteins…

HLA-DRA*01:01-DRB1*04:01  HLA-DRA*01:01-DRB1*15:01  HLA-DRA*01:01-DRB5*01:02

HLA-DPA1*01:03-DPB1*03:01  HLA-DPA1*02:02-DPB1*05:01  HLA-DPA1*02:02-DPB1*15:01

HLA-DQA1*02:01-DQB1*03:03  HLA-DQA1*01:03-DQB1*06:01  HLA-DQA1*01:01-DQB1*06:02

…or discover imusyn’s extensive HLA class II portfolio:

DR Antigens
DP Antigens
DQ Antigens

Elevating Research with High-quality HLA Proteins

imusyn’s high-quality recombinant HLA proteins serve as powerful tools for understanding immune processes, personalised medicine, and advancing therapeutic intervention. Recombinant HLA proteins play a pivotal role in HLA typing and transplantation, ensuring compatibility between donors and recipients during organ transplants. They also contribute significantly to cancer immunotherapy by identifying tumor-specific antigens presented by HLA molecules. Recombinant HLA proteins are essential for vaccine development, allowing the study of immune responses and the design of effective vaccines. Additionally, they facilitate research in areas such as autoimmunity, drug hypersensitivity testing, peptide binding assays, T cell epitope mapping, and antigen presentation studies.

To request a quote, please contact imusyn today.

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