Pressure Modulator for In Vitro Modeling

LivePa is an advanced pressure modulator for in vitro modeling that is designed to bridge the gap between physiological and pathological scenarios. Developed by IVTech this cutting-edge device can simulate dynamic environmental conditions related to disease onset. It is an essential tool that allows researchers to mimic scenarios such as hypertension or glaucoma, providing invaluable insights into disease mechanisms and progression through its advanced pressure modulation capabilities. The LivePa unit is integral to creating dynamic environments that closely mimic real-life biological systems, making it invaluable for researchers in fields such as drug discovery, toxicology, and disease modeling.

Pressure Modulator Advancing Dynamic In Vitro Modeling

LivePa enables an increase in hydrodynamic pressure within dynamic in vitro models, simulating phenomena characterised by heightened pressure. This is particularly useful for replicating disease scenarios like hypertension and glaucoma, or physiological changes due to environmental conditions, such as increased pressure during food ingestion. Equipped with a motorised piston, LivePa reduces the lumen of the outlet tube in a chamber, thereby increasing internal pressure. This functionality is crucial for researchers aiming to create accurate and reliable models of various physiological and pathological states.

Seamless Integration and Compatibility in Fluidic Circuits

Designed with flexibility in mind, the LivePa pressure modulator can be placed into a LiveFlow drawer, ensuring seamless integration into existing laboratory setups. It permits the setup of different rates of pressure increase, allowing customisation for various experimental conditions. LivePa has been thoroughly characterised and is compatible with both the LiveBox1 and LiveBox2 transparent bioreactor models, including LB2 (ALI) and LB2 (LLI). Importantly, LivePa maintains sterility by acting as an external device, reducing the lumen of the outlet tube while preserving sterile conditions during dynamic experiments.

Compact Dimensions and Specifications

LivePa’s dimensions, measuring 8.5 × 2.8 × 1.9 cm, ensure it fits perfectly within a LiveFlow drawer. Its design is tailored to be compliant with LiveFlow environments, enhancing its compatibility and ease of use. The motorised piston mechanism not only increases pressure but also ensures precise control over experimental conditions, making it a reliable addition to any research setup focused on dynamic modeling.

Enhancing Disease Mechanism Research Capabilities

LivePa provides a significant advancement for researchers seeking to replicate dynamic physiological and pathological conditions. By enabling precise control over hydrodynamic pressure, LivePa provides a reliable platform for studying complex biological responses and disease mechanisms under controlled environmental conditions. Its compact design ensures optimal use of laboratory space, facilitating easy transfer between laminar hoods and incubators while maintaining sterile conditions. Compatibility with incubator environments underscores its utility in sensitive biological studies where precise temperature and atmospheric control are crucial.

Transformative Addition to Preclinical Research Facilities

LivePa is a transformative addition to the toolkit of any pharmaceutical or biomedical research facility. Its innovative design and functionality align perfectly with the demands of preclinical studies and drug discovery, offering an efficient and reliable method to explore the complexities of human tissue dynamics. LivePa helps ensure that in vitro models operate under conditions that are as close to in vivo as possible, thereby improving the accuracy and relevance of experimental results. By facilitating the development of dynamic models, LivePa accelerates the path to groundbreaking discoveries and therapeutic advancements, enhancing the scope and depth of research capabilities.

Features & Benefits of the LivePa Pressure Modulator

Main Features:

• Dimensions: 8.5×2.8×1.9 cm
• Compatibility: Compatible with the LiveFlow drawer
• Pressure Modulator: Equipped with a motorised piston to reduce the lumen of the outlet tube, increasing pressure

Benefits:

• Simulates disease scenarios like hypertension and glaucoma
• Mimics physiological changes such as increased pressure during food ingestion
• Enhances the versatility of dynamic in-vitro models by allowing precise pressure adjustments