Parkinson’s Disease is characterized by the aggregation of alpha-synuclein, a key pathological feature. In this informative video, the mechanism underlying this aggregation process is explained, along with StressMarq’s groundbreaking contributions. By utilizing StressMarq’s pre-formed fibrils (PFFs) and oligomers, researchers can effectively induce this aggregation phenomenon in both cellular models and animal brains. These specialized research tools provided by StressMarq empower scientists to develop accurate disease models and conduct thorough evaluations of potential drug candidates, opening new avenues for effective treatments for Parkinson’s Disease.
Parkinson’s Disease Modelling with Alpha Synuclein Pre-Formed Fibrils and Oligomers
The utilization of StressMarq’s alpha synuclein pre-formed fibrils (PFFs) initiates the formation of fresh fibrils from active alpha-synuclein monomers. These PFFs serve as catalysts, inducing endogenous phosphorylation of alpha-synuclein and leading to the subsequent development of Lewy body inclusions within neuronal cell cultures. Furthermore, StressMarq’s PFFs are invaluable tools for conducting in vitro studies on oligomerization, providing researchers with a means to explore this crucial aspect of alpha-synuclein pathology.
Cutting-edge Neuroscience Research Tools
StressMarq Biosciences has created a diverse assortment of protein preparations encompassing monomeric, fibrilized, and oligomeric forms. These meticulously developed protein variants cater to the specific requirements of neurodegenerative disease research, covering a comprehensive range of proteins such as alpha-synuclein, beta-synuclein, gamma-synuclein, tau, amyloid beta, SOD1, and TTR. By offering this extensive array of protein preparations, StressMarq Biosciences equips researchers with the necessary tools to delve into various facets of neurodegenerative diseases and advance our understanding of their underlying mechanisms.
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