Tau is a key protein implicated in neurodegenerative diseases, such as Alzheimer’s and dementia.
Tau Pre-formed Fibrils (PFFs) for Modelling of Neurodegenerative Diseases
StressMarq Biosciences is the pioneering provider of active tau preformed fibrils (PFFs) and filaments, exclusively developed for cutting-edge neuroscience research. These active tau PFFs possess the unique capability to initiate the process of tau aggregation by recruiting monomers and facilitating the formation of larger tau fibrils. This phenomenon has been convincingly demonstrated in thioflavin T assays, where the combination of active tau PFFs and active tau monomers leads to a notable increase in fluorescence, serving as a clear indication of tau fibrillization. Moreover, in experiments involving P301L mice, specific tau PFFs have been injected, successfully triggering tau aggregation and inducing tau pathology specifically in the hippocampus region.
Novel Tools for Cutting-edge Neuroscience Research
StressMarq Biosciences specializes in the production of tau fibrils, filaments, and antibodies specifically designed for advancing Neurodegenerative disease research. These serve as valuable tools for disease modeling in both cellular and rodent studies, enabling researchers and scientists to evaluate the efficacy of potential drug candidates and facilitate the development of innovative therapeutic approaches.
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