Labeled Compounds for Pharmaceutical Research

Expert Synthesis Solutions (ESS) is a trusted provider of high-purity labeled compounds, offering cost-effective solutions for pharmaceutical, biotech, and analytical testing laboratories worldwide. With a unique catalog that includes exclusively manufactured and rare isotopically labeled compounds, labeled steroids and reference standards, ESS enables cutting-edge research, drug development, and testing with unparalleled accuracy and reliability.

Labeled Compounds for Pharmaceutical Research

The company’s portfolio includes more than 200 labeled compounds, including many unique and rare compounds:

  • Isotopically Labeled Compounds – Deuterium-labeled (D-labeled) and carbon-13-labeled (13C-labeled) compounds critical for drug metabolism, bioavailability, and analytical testing.
  • Labeled Steroids – Deuterated steroids serve as precise internal standards in hormone research, LC-MS/MS assays, and drug development.
  • Labeled Reference Standards – Used in method validation, stability studies, and quality control processes across pharmaceutical and biotech research.

These compounds are indispensable tools for quantitative bioanalysis, ADME studies, and internal standards for LC-MS/MS assays. By ensuring isotopic purity and structural integrity, the ESS labled compounds serve as essential resources for pharmaceutical research and development.

Uncompromising Purity and Quality Assurance

Each labeled compound undergoes stringent quality control and verification for isotopic enrichment and chemical purity using state-of-the-art analytical techniques, including high-performance liquid chromatography (HPLC) and nuclear magnetic resonance (NMR) spectroscopy. Expert Synthesis Solutions ensures that every product meets the highest industry standards, providing researchers with reference materials of exceptional quality and reproducibility. A Certificate of Analysis with detailed analytical data is available for each compound on the ESS web store.

Labeled Compounds Applications in Drug Discovery

  • Pharmaceutical Development: Labeled standards play a crucial role in bioavailability and bioequivalence studies, supporting drug metabolism and interaction assessments.
  • Biotechnology Innovations: Essential for proteomics, biomarker discovery, and molecular biology applications.
  • Analytical Testing Labs: Used in quantitative bioanalysis, LC-MS/MS assays, and stability testing to ensure compliance with regulatory standards.

Featured Labeled Compounds

The company’s labeled compounds catalog includes a diverse selection of high-purity products, such as:

Isotopically Labeled Compounds

Deuterium-labeled (D-labeled) Compounds:

Amoxicillin-D4 (major)
CAT#: ESS0175
 CAS#: 26787-78-0 (unlabelled)
 Purity: 99.7% by HPLC: >98% atom D
 MF: C16H15D4N3O5S     MW: 369.43
 Inventory status: IN STOCK
Application: Widely used in antibiotic research, pharmacokinetic (PK) studies, and bioanalytical method development.

Bictegravir-D4
CAT#: ESS0485
 CAS#: 1611493-60-7 (unlabelled)
 Purity: 97.2% by HPLC; >98% atom D
 MF: C21H14D4F3N3O5   MW: 453.40
 Inventory status: IN STOCK
Application: Used in HIV drug development, DMPK studies, and quantification in plasma/serum assays.
Cyclosporin A-D4
CAT#: ESS0169
 CAS#: 59865-13-3 (unlabelled)
 Purity: 98% by HPLC; >98% atom D
 MF: C62H107D4N11O12     MW: 1206.64
 Inventory status: IN STOCK Application: Commonly used in immunosuppressant research, therapeutic drug monitoring (TDM), and transplant studies.

Carbon-13-labeled (13C-labeled) Compounds:

Tacrolimus-13C, D2 (major)
CAT#: ESS0447
 CAS#: 1356841-89-8
 Purity: 98.4% by HPLC; 99% atom 13C; >85% atom D
 MF: C₄₃¹³CH₆₇D₂NO₁₂  MW: 807.02
 Inventory status: IN STOCK Application: Highly sought after for immunosuppressant drug research and therapeutic drug monitoring.
Rapamycin-13C, D3
CAT#: ESS0567
 CAS#: 392711-19-2 (D3 form)
 Purity: 97.0% by HPLC; 99% atom 13C; 99.5% atom D
 MF: C5013CH76D3NO13   MW: 918.18
 Inventory status: IN STOCK Application: An essential internal standard for mTOR pathway research and metabolite profiling in oncology studies.
Triflusal-13C6
CAT#: ESS0157
 CAS#: 322-79-2 (unlabelled)
 Purity: 97.0% by HPLC; 99 atom % 13C
 MF: C4(13C6)H7F3O4     MW: 254.11
 Inventory status: IN STOCK Application: A preferred internal standard for antiplatelet drug research and metabolic stability testing in cardiovascular studies.

Labeled Steroids

Hydrocortisone-D4
CAT#: ESS0407
 CAS#: 73565-87-4
 Purity: 97.9% by HPLC; >98% atom D
 MF: C21H26D4O5   MW: 366.49
 Inventory status: IN STOCK Application: A key reference standard for steroid hormone research and analytical method validation.
20α-Dihydrodydrogesterone-D7 (major)
CAT#: ESS0565
 CAS#: 4243-74-7 (unlabeled)
 Purity: 99.7% by HPLC; >98% atom D
 MF: C21H23D7O2   MW: 321.51
 Inventory status: IN STOCK Application: A vital internal standard for hormone replacement therapy studies and progesterone receptor research.


Fulvestrant-D5
CAT#: ESS0118
 CAS#: 129453-61-8 (unlabeled)
 Purity: 99.7% by HPLC; >98% atom D
 MF: C32H42D5F5O3S     MW: 611.81
 Inventory status: IN STOCK
Application: A crucial internal standard for estrogen receptor degradation studies and breast cancer research assays.

Cost-Effective Labeled Compounds with Global Availability

Expert Synthesis Solutions (ESS) provides highly cost-effective R&D-grade labeled compounds, delivering exceptional quality and reliability at competitive prices. The ESS inventory of in-stock labeled compounds is available for immediate purchase through the company’s online store. For large-scale supply needs, bulk inquiries are welcomed through the contact forms.

While ESS is not ISO certified and does not offer certified standards, all products undergo rigorous in-house testing and validation to ensure the highest standards of purity and performance. Because of the uncompromising quality and affordability of the ESS compounds, clients can easily certify them in-house as required. This approach allows researchers to bypass the costs associated with ISO certification when using compounds only for R&D purposes. 

ESS provides full transparency, and every in-stock compound includes a Certificate of Analysis (CofA) on the company’s website, complete with detailed analytical data. Researchers can review this information upfront, enabling them to make informed purchasing decisions tailored to their needs.

By emphasizing accessibility, transparency, and affordability, ESS enables researchers to acquire reliable labeled compounds tailored to their needs while retaining flexibility to address compliance requirements when necessary.

Why Choose Expert Synthesis Solutions?

✔ High-purity R&D-grade compounds
✔ Catalog of more than 200 labeled compounds
✔ Exclusively manufactured and rare labeled compounds
✔ All synthesized in-house for guaranteed quality and consistency
✔ Certificate of Analysis (CofA) for every in-stock product
✔ Cost-effective R&D compounds
✔ No ISO overhead ensuring competitive pricing
✔ Easy Client-driven ISO certification options
✔ Ready-to-ship availability
✔ Global delivery via a secure supply chain

For more information and to explore the full catalog, visit ESS Labeled Compounds.

Expert Synthesis Solutions continues to drive innovation in pharmaceutical research by delivering precision, reliability, and affordability in labeled compounds.


Request a Quote


    • ESS LOGO Large 1 768x495

    EXPERT SYNTHESIS SOLUTIONS