Company Categories: 3D Drug Screening, Drug Delivery Systems, Drug Development, Drug Discovery, Laboratory Equipment and Microscopy Equipment
Innovative Particle Characterisation Instruments
DetailsXtal Concepts is an innovative technology company specialising in the development and production of cutting-edge measuring instruments for the characterisation of nano- and microparticles in liquids. Xtal is a leader in the field of Dynamic Light Scattering (DLS) providing groundbreaking solutions for modern analysis techniques.
The company’s unique DLS particle characterisation instruments empower researchers and scientists from leading pharmaceutical, biotech, laboratory and academic research organisations to explore the world of nanoscale and microparticle analysis with unprecedented speed and highly advanced precision and efficiency. With robust development capabilities, beyond advanced modularity, Xtal also provides highly customised products tailored to meet individual research needs.
Breakthrough Dynamic Light Scattering (DLS) Particle Characterisation Technology
Xtal Concepts manufactures and distributes a unique line of Dynamic Light Scattering (DLS) nano- and microparticle characterisation instruments and imaging systems that transform scientific and pharmaceutical research methodologies.
Their product portfolio includes sophisticated DLS benchtop instruments that can assess the complete range of particle sizes found in biochemistry. The groundbreaking in situ or ‘in plate’ DLS technology enables particle size determination in previously unattainable small sample volumes.
Xtal’s in situ DLS instruments provide an exceptionally time and sample-efficient method of obtaining particle size information from multiple sub-µl samples in a single run, without the need for sample preparation.
The unique features of the in situ DLS instruments empower researchers to break the glass ceiling in nanoparticle characterisation and detect even minute changes in particle sizes gaining key insights to optimising drug formulations, gene therapy and vaccine development.
Automated Dynamic Light Scattering (DLS) Particle Sizing Instruments
The SpectroLight 600/610 represents a significant leap in analytical instrumentation design and technology. As a fully automated Dynamic Light Scattering (DLS) particle sizing instrument with an integrated microscope, it combines exceptional accuracy and versatility, making it an indispensable tool for various laboratory applications. This compact yet powerful in situ DLS benchtop device seamlessly integrates into laboratory workflows, whilst offering unparalleled insights into particle behaviour and characteristics.
Particle Sizing in Unmatched Small Sample Volumes with in situ DLS
The technical realisation of in situ DLS enables ultra-precise particle size determination in unmatched small sample volumes, ranging from 0.08 µl to 1 µl. Particle size determination by in plate DLS also offers high reproducibility with a deviation of only ±2%. Whether studying nanoparticles, proteins, virus particles, or colloidal systems, this instrument is a game-changer delivering fast, highly reliable and reproducible results.
For example, the in situ DLS technology reveals insights into the behaviour of adenoviral vectors, typically sized between 0.08 µm – 0.11µm. Understanding their assembly dynamics, and the role of size distribution in their functionality is essential for optimising gene therapies and vaccine development.
Seamless DLS Integration and Workflow Optimisation
The SpectroLight 600/610 system’s compatibility with standard 96-well plates ensures seamless integration into existing laboratory setups. Researchers have the convenience of using diverse sample formats without cuvettes, special consumables, or cleaning.
The system enables precise positioning within the sample and automated screening for pH, detergents, buffers, and other conditions. By using a minimal sample volume of only 9.6 µl, researchers gain insights into their sample’s well-being across a full plate with 96 conditions. The plates can be reused for measurements over several weeks, enhancing data reliability.
The SpectroLight 600/610 incorporates a fully integrated laboratory microscope. Researchers can visually inspect samples, detecting colloidal or solid contaminants to enhance sample quality assessment. Additionally, the optional UV imaging allows rapid crystal identification.
The versatile DLS device is ideal for many laboratory applications such as sample quality or stability analysis, buffer screening, monodispersity determination, and workflow monitoring. Its impact extends beyond particle characterisation contributing to informed decision-making, data quality, faster research, and drug development cycles.
Plate Hotel System with DLS and Imaging Functionality
SpectroQ stands at the forefront of innovation, merging the capabilities of DLS and imaging within a single, highly sophisticated plate hotel system. Unlike conventional imaging systems that serve primarily for protein crystal identification and detection, SpectroQ transcends these limitations, offering a host of advanced features that redefine sample analysis.
It can store and process standard crystallisation plates in a temperature-controlled environment, allowing researchers to study various aspects of protein interactions, quality assessment, and molecular behaviour.
SpectroQ is more than just a hotel system, it is an exceptionally versatile tool that offers repetitive DLS, automated imaging, protein buffer screening, and long-term stability monitoring. SpectroQ simplifies the crystal imaging workflow and enables new analytical possibilities. This innovative system is a game-changer for scientists, researchers, and quality control professionals who want to explore new dimensions in sample analysis.
Fully Automated Desktop Imaging System
The XtalLight 200/210 is a truly modern fully automated desktop imaging system, engineered for rapid and high-quality imaging of standard crystallisation plates. This system is upgradeable to a high-performance dynamic light scattering (DLS) device, becoming the SpectroLight 600/610.
Utilising bright light and UV-imaging capabilities, coupled with automated drop finding and trace fluorescence imaging, it ensures rapid and accurate identification of crystallisation hits. In addition to crystal hit identification, XtalLight 200/210 serves a wide range of applications, ranging from trace and intrinsic fluorescence imaging to aptamer identification and LCP crystal identification. Bright and UV-light imaging, enable precise localisation of protein contents and the distinction between salt and protein crystals.
The system’s intuitive GUI allows for quick and uncomplicated access to acquired imaging data, streamlining the entire process for researchers.
UV-Light Source Device
The XtalLight 100 is a specialised UV-light source device adaptable to laboratory microscopes that provides protein sample illumination for various applications.
The UV-light source device enables protein crystal identification by exciting the intrinsic tryptophan fluorescence of protein and salt crystals. This allows for rapid and accurate differentiation of crystal types during protein crystallography, distinguishing salt from protein crystals there and then.
The XtalLight 100 UV-light source upgrade for standard laboratory microscopes enhances the illumination of the sample without interfering with microscope optics. With the optional camera and analysis package the XtalLight 100 also becomes a remarkably cost-effective imaging system.
The XtalLight 100 is a valuable tool for protein sample illumination, as it improves the sample preparation and analysis for modern techniques such as X-ray crystallography and UV-light microscopy. The XtalLight 100 delivers reliable and versatile UV-light illumination, ensuring accurate and meaningful results.
About Xtal Concepts
Xtal Concepts, established in 2012 in Hamburg, is a pioneering technology company specialising in the development, manufacturing, and commercialisation of cutting-edge measuring instruments tailored for nano- and microparticle characterisation in liquid environments.
Xtal Concepts consistently delivers state-of-the-art, reliable, and user-friendly instruments, facilitating breakthroughs in various scientific and pharmaceutical research disciplines. Xtal Concepts remains at the forefront of innovation with groundbreaking Dynamic Light Scattering (DLS) technology. This technology enables precise measurement of particle sizes in liquid mediums at submicroscopic levels, revolutionising research methodologies.
Xtal Concepts’ next-generation DLS laboratory benchtop particle characterisation instruments are reshaping scientific research, drug discovery, and development studies across a multitude of domains. Trusted by leading pharmaceutical and biotherapeutics firms, as well as esteemed research institutions and universities worldwide, these instruments are at the forefront of progress and innovation.
Products
Dynamic Light Scattering (DLS) Particle Size Analyzer
The cutting-edge Dynamic Light Scattering (DLS) Particle Size Analyzer is a powerful benchtop device that enables precise particle size determination in plates with …
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Schnackenburgallee 13
22525 Hamburg
GermanyPhone: +49 40 181 444 49
