Company Categories: 3D Drug Screening, Cell Line Development, Drug Development, Drug Discovery, Laboratory Equipment, Organ-on-chip and Preclinical Toxicology
Next-Generation Organ-On-Chip Models
DetailsAKITA® delivers next-gen Organ-On-Chip models for drug development, designed to revolutionise the fields of drug discovery, toxicology, and biological research.
Developed by Finnadvance, the AKITA® platform provides high-throughput, humanised in-vitro models that replicate microphysiological conditions of essential human tissues with exceptional accuracy. These cutting-edge Organ-On-Chip systems leverage groundbreaking bioengineering to bridge the gap between traditional cell culture methods and actual human biology. By mimicking the complex dynamics of in-vivo environments, AKITA® Organ-On-Chip models enhance the predictability and reliability of preclinical studies, supporting research areas such as cancer and immune cell migration, inflammation, safety testing, and drug permeability.
High-Precision Organ-On-Chip Models
AKITA® includes a suite of Organ-On-Chip platforms that simulate human tissues with remarkable accuracy. These models are engineered to support various tissue types, including:
Blood-Brain Barrier: Mimics human blood-brain barrier (BBB) function with endothelial cells and astrocytes, replicating in-vivo conditions for accurate drug permeability and neurotoxicity testing.
Lung/Airway Tissue: Replicates the lung’s air-liquid interface, using A549 cells to showcase airway cilia structures, critical for respiratory studies.
Gut Epithelial Barrier: Uses Caco2 cells and blood vessel endothelial cells to emulate the human gut, ideal for assessing oral drug permeability.
Vascular Endothelial Barrier: Facilitates the creation of lumenized vessels for examining rolling adhesion, cancer cell interactions, and chondrocyte culture applications.
These advanced in-vitro models enable researchers to study complex biological processes, evaluate drug responses, and conduct toxicology tests in physiologically relevant conditions that closely mimic human tissues.
Groundbreaking In-vitro Models for Drug Discovery
The AKITA® platform offers a transformative solution for researchers in drug discovery, toxicology, and biomedical research, setting a new standard in human-relevant in-vitro models. As the highest-throughput Organ-On-Chip platform globally, it combines unparalleled scalability with precision, enabling researchers to conduct extensive high-throughput screening under physiologically relevant conditions.
By reconstituting biological barriers in the widely used well-plate format and providing dynamic fluid flow without pumps, AKITA® models accurately mimic the complex microenvironments cells encounter in the human body. This ensures more predictive and reliable results in preclinical studies, allowing for better evaluation of drug efficacy and toxicity. The platform supports electrical sensing and is compatible with all optical measurement techniques, facilitating comprehensive data analysis.
By reducing reliance on animal testing, AKITA® not only accelerates drug development but also promotes ethical and sustainable research practices.
AKITA® Plate – Versatile Microfluidic Culture Platform
The groundbreaking AKITA® Plate provides a high-throughput solution for drug screening and tissue culture. This microfluidic culture platform, designed in the familiar high throughput well plate format, allows for dynamic and static culturing conditions, tailored for various types of biological barriers:
Microphysiological Conditions: Endothelial cells experience constant flow conditions, while epithelial cells are maintained in either submerged or air-liquid interface states, mimicking in-vivo environments.
Scalable Formats: Available in both 96-well and 384-well plate formats, AKITA® Plate allows for scalability in experimental design. The 96-well format supports 24 replicates per plate with larger volumes (150 μL), while the 384-well format allows for up to 96 experiments per plate with reduced volumes (30 μL), optimising high-throughput screening.
High-Resolution Imaging Compatibility: AKITA® Plates are designed with a standard SBS footprint, compatible with multiple imaging techniques, including confocal microscopy, digital holography, ultrasound, electron microscopy, and MRI, making it a versatile choice for high-content imaging applications.
AKITA® Lid – Enhanced Throughput with TEER Measurement
The AKITA® Lid complements the AKITA® Plate, enabling simultaneous Trans Epithelial Electrical Resistance (TEER) measurements across 96 wells. TEER is essential for assessing barrier integrity in layered cell cultures, providing non-optical, continuous data on cell health and viability:
Multi-Channel TEER Measurement: Conducts up to 96 simultaneous measurements with frequencies ranging from 1Hz to 200kHz, ensuring reliable barrier assessments.
Wireless and Remote Monitoring: Equipped with a wireless monitoring system, the AKITA® Lid allows researchers to track results in real-time, streamline data collection, and synchronise multiple devices for large-scale experiments.
AKITA® Wave – Pump-Free Dynamic Fluid Manipulation
The AKITA® Wave system offers dynamic fluid flow within the AKITA® Plate’s microchannels, emulating physiological fluid dynamics without the need for external pumps:
Controlled Rocking Motion: AKITA® Wave uses an adjustable rocking mechanism to maintain consistent perfusion across the plate, enabling continuous media exchange and nutrient delivery.
Fully Compatible with Standard Incubators: Designed to fit all standard incubators, AKITA® Wave supports high-throughput operations, allowing for up to 20 units to be synchronized and monitored through a mobile app.
Accelerating Drug Discovery and Pharmaceutical Research
The AKITA® Platform addresses multiple research needs in drug discovery, toxicology, and therapeutic development including:
Neuroscience and BBB Studies: Enables reliable modeling of the blood-brain barrier, supporting neurological studies and neurotoxicology research.
Respiratory Research: Simulates the lung’s air-liquid interface, aiding in respiratory drug testing and pulmonary disease modeling.
Gut Barrier Studies: Facilitates drug permeability assessments for oral medications, simulating the human gut barrier.
Oncology and Vascular Research: Allows for studying cancer cell adhesion, vascular behaviour, and niche generation in 3D environments.
The Highest-throughput Organ-On-Chip Platform in the World
The AKITA® Plate presents the highest-throughput Organ-On-Chip platform in the world. It enables extensive high-throughput drug screening and tissue culture experiments under carefully controlled microphysiological conditions.
AKITA® Plates are available in both 96-well and 384-well formats to support diverse research requirements. The 96-well format accommodates larger volume experiments, ideal for high-replicate studies, while the 384-well format allows for even higher throughput screening at reduced volumes, perfect for testing large compound libraries.
Both plate formats are compatible with high-content imaging techniques, including confocal microscopy, digital holography, electron microscopy, and MRI, allowing researchers to capture detailed data across multiple imaging modalities. The standard SBS footprint of the AKITA® Plate enhances usability, making it an intuitive and accessible choice for Organ-On-Chip studies in labs around the world.
Flexible Options for Diverse Research Needs
The AKITA® product range includes a variety of plate formats and materials, that can be selected to fit specific research needs. AKITA® Plates come with multiple pore sizes and materials, including PET membranes and Bio-Spun scaffolds, which enhance cell adhesion and support complex experimental setups. Researchers can select from individual plates or multipack options, with starter kits available that include potent coatings to optimise the growth conditions of specific cell types.
In addition to core products, Finnadvance provides accessories such as the AKITA® Wave Rocker, custom TEER devices, and adapters, creating a complete ecosystem for Organ-On-Chip research. This wide range of customisable options allows scientists to mix and match components, tailoring the AKITA® platform to their unique research objectives.
About AKITA® by Finnadvance
Established as a product line by Finnadvance Ltd., an innovative Finnish biotechnology company, AKITA® aims to accelerate drug development and improve the accuracy of in-vitro testing by providing scalable, humanised Organ-On-Chip models. Finnadvance is dedicated to transforming research practices to make them more efficient, cost-effective, and translatable to human biology. The company was founded with a deep commitment to improving preclinical research, a passion that continues to guide its efforts to develop breakthrough biotechnology solutions.
The AKITA® product range is designed to enable the rapid development of innovative therapies and to contribute to a healthier, more equitable world. Driven by a mission to create a better life for all, AKITA® serves to make drug discovery faster, more efficient, and more accessible, reducing costs for both pharmaceutical companies and patients. By providing researchers with sophisticated tools that produce more accurate results, AKITA® is fostering advancements in medicine that will benefit global health.
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Haartmaninkatu 4
00290 Helsinki
FinlandPhone: +358 40 6537049
