Utilising Surface Plasmon Resonance (SPR) analysis for drug development or drug discovery can make a big impact.
SPR analysis can be used to determine the precise binding kinetics, specificity and concentration between antibodies/antigens, recombinant receptors, ligands or compounds with low molecular weight, such as drug candidates. Applying SPR technology to analyse the binding of small molecules can significantly increase a drug discovery or development program’s chances of success.
Biomolecular interaction analysis using Surface Plasmon Resonance (SPR)
Surface Plasmon Resonance (SPR; Biacore) analysis to explore biomolecular interaction involves the use of optical sensor chips for real-time detection of molecular binding.
Identification and characterisation of target molecules using SPR includes:
- Binding Kinetics
- Epitope Mapping
- Biosimilar Profiling
- Potency and Similarity Assay Development
Biacore SPR technology can be used in a variety of research and drug discovery and development settings.
Surface Plasmon Resonance (SPR) analysis for drug discovery and drug development
Utilising SPR can have a high impact on drug discovery and development. Small molecule drug discovery and development is known to be an expensive and time-consuming endeavour, which is not always successful. The significant investment needs and relatively low success rates require the adoption of technologies such as SPR to quickly and accurately measure the activity and binding characteristics of target molecules throughout the entire discovery and development process.
SPR is frequently used for target identification and ligand fishing in proteomics, target assay validation for High Throughput Screening (HTS), rapid affinity ranking and detailed kinetics of interaction for small molecules binding to target proteins, lead optimisation, early ADME, stratification of patient response to therapeutics in clinical trials, immunogenicity assessment including anti-drug antibody (ADA) responses of biotherapeutics, vaccine development including immune response analysis, and even in manufacturing such as process and batch QC of therapeutic antibodies and proteins.
About NBS-C BioScience SPR technology
Applying SPR technology for almost three decades, NBS-C BioScience, has gained extensive expertise utilising SPR in numerous R&D applications for leading pharma, biotech, research and academic institutions around the world. Understanding the needs of researchers and drug developers NBS-C BioScience is a brilliant partner in SPR projects.