Microbroth Dilution Testing Services
Antiinfectives Intelligence (Aii) offers cutting-edge Microbroth Dilution testing services, recognised as the gold standard for determining the Minimum Inhibitory Concentration (MIC) of antibiotics. This precise methodology allows pharmaceutical companies to pinpoint the lowest concentration of an antibiotic required to inhibit bacterial growth. By leveraging Aii’s expertise, clients can refine their antimicrobial therapies, ensuring they are both effective and efficient. This microbroth dilution-based testing service is critical for the development of new drugs in the fight against resistant pathogens, providing a foundation for safe and effective treatments.
Microbroth Dilution Testing to Determine the MIC of Antibiotics
Aii employs an advanced microbroth dilution technique to determine the MIC of antibiotics against targeted bacterial strains. Renowned for its accuracy, this method identifies the minimal concentration needed to suppress bacterial growth, empowering pharmaceutical companies to improve their antimicrobial treatment strategies and contribute to the global fight against resistant pathogens.
Monitoring Antibiotic Resistance with Microbroth Dilution
In the face of rising antibiotic resistance, Aii’s Microbroth Dilution services play a crucial role in monitoring the antimicrobial effectiveness of substances. By determining the susceptibility of clinical isolates to antibiotics in microtiter plates, Aii provides essential data that optimise treatment strategies and support the development of new antibiotics.
Precise Antibiotic Testing Under ISO 20776-1 and CLSI M07-A10 Standards
All testing at Aii is conducted according to the ISO 20776-1 and CLSI M07-A10 standards, ensuring the highest level of accuracy and reliability. Using microtiter plates – 96-well polystyrene plates – Aii can test single or multiple antibiotics. Whether using industry-standard lyophilized plates or custom in-house plates, Aii tailors its testing to meet the unique needs of each project.
Customised Microtiter Plate Preparation for Precise Testing
Aii offers a customisable testing service that includes the design and preparation of microtiter plates according to client specifications. Each plate is meticulously prepared, including growth and sterile controls, to maintain stringent experimental conditions. Plates can be pre-frozen for future testing or freshly prepared on the test day for exceptional precision. This flexibility allows pharmaceutical companies to address specific research goals and requirements, ensuring that every project is handled with care and expertise.
Accurate MIC Determination and Interpretation
Following incubation, Aii identifies the lowest antibiotic concentration that inhibits visible growth of the test organism. Interpretation of results is based on EUCAST breakpoint tables, determining whether the organism is resistant or sensitive. This precise determination is vital for pharmaceutical companies in assessing the efficacy of antimicrobial agents and making informed decisions during the drug development process.
Comprehensive Support in Antimicrobial Development and Surveillance
Aii’s microbroth dilution services are available for resistance surveillance studies and testing the in vitro activity of antibiotics. This comprehensive support spans the development, approval, and subsequent monitoring of antimicrobial substances, ensuring that pharmaceutical partners receive high-quality, reliable data to advance their research and development efforts.
Complete Solution with Personalised Planning and Professional Consultation
Aii offers a complete solution that includes individual planning with clients, conducting tests, regular updates on results, professional advice on adaptations of the test procedure, and the option for detailed reporting and manuscript preparation. This holistic approach ensures that pharmaceutical companies are well-equipped with the necessary data and insights to drive their antimicrobial research forward.
Resistance Monitoring for Better Outcomes
Antiinfectives Intelligence also provides resistance monitoring using microbroth dilution, enabling companies to evaluate the antimicrobial effectiveness of their substances against clinical isolates. This service is indispensable for resistance surveillance studies, offering a proactive approach to ensuring that antibiotics maintain their efficacy in the face of evolving bacterial resistance.
Enhanced Efficiency through Microbroth Dilution Services
Utilising Aii’s microbroth dilution services offers pharmaceutical companies significant advantages in streamlining the drug development process. The method’s high throughput capacity allows for the simultaneous testing of multiple compounds, accelerating the screening phase and enabling rapid identification of promising candidates. This efficiency not only reduces time-to-market but also lowers research and development costs. Furthermore, the precise and reproducible MIC data generated through this standardised method provide a solid foundation for regulatory submissions, facilitating smoother approval processes. By partnering with Aii, pharmaceutical companies can leverage expert methodologies and comprehensive support, ultimately enhancing the success rates of their antimicrobial development projects.
Minimal Bactericidal Concentration (MBC) testing
Beyond MIC testing, Aii specializes in Minimal Bactericidal Concentration (MBC) testing, which determines the concentration required to kill 99.9% of bacterial cells. This data is pivotal for pharmaceutical companies aiming to develop drugs that do more than inhibit growth -they eliminate pathogens entirely. By reducing the risk of recurrence and combating resistance development, Aii’s MBC testing empowers pharmaceutical innovators with the insights needed to create next-generation antimicrobials.
Expert Support and Comprehensive Reporting
From initial consultation to final reporting, Aii provides a complete solution for antimicrobial testing. Clients benefit from:
- Individualized project planning tailored to their needs.
- Ongoing updates throughout the testing process.
- Professional advice on optimizing test procedures.
- Comprehensive final reports in German or English, optionally formatted for regulatory or publication purposes.
Partnering for Success in Antimicrobial Development
Antiinfectives Intelligence is more than a testing service – it’s a strategic partner in the development, approval, and post-market monitoring of antimicrobial agents. With an emphasis on precision, adaptability, and client collaboration, Aii ensures pharmaceutical companies have the tools and insights necessary to succeed in a highly competitive industry.
Contact Antiinfectives Intelligence today for expert advice on elevating your antimicrobial research and development efforts.
Quick Contact Form – Antiinfectives Intelligence
Alternatively please email Aii’s experts directly at team@antiinfectives-intelligence.de or visit the company’s website for more info on their comprehensive offerings: www.antiinfectives-intelligence.de