Device for Visual Acuity Testing of Laboratory Animals

The cutting-edge AcuiSee device for visual acuity testing of laboratory animals stands out as a breakthrough in the realm of visual neuroscience research technology.

The AcuiSee device automatically determines the visual abilities of a wide range of laboratory animals, by employing a non-invasive operant conditioning method, providing accurate analysis to quickly and objectively determine visual acuity and contrast sensitivity.

Device for Visual Acuity Testing of Laboratory Animals

The AcuiSee device is a groundbreaking innovation, setting a new standard for the determination of visual abilities in laboratory animals.

Based on the operant conditioning method, also known as instrumental conditioning, the AcuiSee device is a testament to the fusion of technology and science, pioneering fully automated and non-invasive in vivo analysis that swiftly and objectively measures visual acuity and contrast sensitivity, and other aspects such as movement vision. Additionally, the AcuiSee specialised box is adaptable to various animal models enabling the testing of a broad range of research subjects, from mice to rats, ensuring it fulfils the wide-ranging requirements of the preclinical research and drug discovery sectors.

Revolutionising In Vivo Preclinical Research

This visual acuity testing device is particularly important for in vivo preclinical research, where automated, fast and non-invasive methods are key for reproducibility and informed yet cost-effective decision-making. AcuiSee’s ability to deliver quick and objective results through automated animal training and without a behaviourist on-site makes it an invaluable asset in the drug discovery sector. It automates and streamlines the research process, saving valuable resources and allowing researchers to focus on the application of data for the development of novel therapeutics.

A Multifaceted Tool for Visual Neuroscience Research

The AcuiSee device is a multifaceted tool for visual neuroscience research, invaluable for a wide range of applications. Mirroring the capabilities of the unique OptoDrum system, which is based on optomotor reflex methodology, AcuiSee also excels in fields such as ophthalmology, pharmacology, disease modeling, and toxicology, and its utility extends further into cognitive behaviour studies.

In ophthalmology, the AcuiSee device can be utilised for the measurement of visual acuity and contrast sensitivity.  This is crucial for understanding the progression of retinal deterioration and the success of innovative therapies, such as those involving stem cells, optogenetics, and neuroprotective strategies. In pharmacology, AcuiSee is ideal for the safety and effectiveness testing of ophthalmic drugs, while also serving as a valuable tool in disease modeling for conditions like retinal degeneration, glaucoma, axon degeneration, multiple sclerosis, neuroinflammation, diabetes, stroke and ageing. Its non-invasive, automated approach ensures high-throughput screening in toxicology, assessing the impact of environmental stress and neurotoxic substances on visual health. Furthermore, AcuiSee’s capabilities extend to cognitive behavior studies, to explore how visual impairments impact cognitive functions.

Fully Compliant and Cost-Effective In Vivo Research Solution

AcuiSee not only stands at the forefront of visual acuity testing technology but is also fully compliant with Good Laboratory Practice (GLP) guidelines, guaranteeing that the system adheres to the highest standards of quality and integrity in safety and toxicological evaluations.

The system is designed to be cost-effective and efficient, requiring minimal training for personnel. The system’s accompanying software provides an intuitive interface and can take charge of the process, automating it to allow for high-throughput testing of trained animals for low labour and large studies. Researchers can monitor animal activity remotely over Wi-Fi, adding an extra layer of convenience. Moreover, up to 256 AcuiSee testing chambers can be controlled simultaneously with a single control tablet, maximising productivity and streamlining the research process. The innovative device for visual acuity testing of laboratory animals also offers advanced flexibility and ease of handling. It is ready to use right out of the box, eliminating the need for complex setup procedures. The device is highly adaptable, allowing researchers to implement static, moving, or custom image sets based on their specific research needs.

Streamlined Three-step In Vivo Testing of Laboratory Animals

The AcuiSee testing procedure is a streamlined three-step process designed to assess the visual acuity of laboratory animals. Initially, animals undergo a period of food deprivation and chamber acclimation to prepare them for the experiment. The training phase involves two daily sessions where animals learn to distinguish between visual patterns on touch panels, with correct choices rewarded with food, leading to a criterion performance typically achieved within 10-14 days. The final testing phase challenges the animals with progressively difficult visual targets to accurately determine their visual threshold.

The AcuiSee system embodies the commitment to automated, non-invasive, precise, and efficient research methodologies. As a comprehensive tool, AcuiSee is poised to propel researchers to new heights in the quest to treat visual disorders and enhance the quality of life for those affected by them. Its user-friendly design and advanced features make it an essential tool for any laboratory engaged in visual neuroscience and drug discovery research.

AcuiSee Device Features

• Fully automated visual performance measurement
• Objective and fast in vivo assessment
• Tests a wide range of small laboratory animals
• Non-invasive – No fixation or surgery required
• Supports numerous preclinical research applications
• Cost-saving and effective
• Streamlined three-step testing process
• User-friendly software package included
• Remote activity monitoring over Wi-Fi