The Caco-2 Permeability Cell-based Plates offer a ready-to-use solution for evaluating the in vitro intestinal absorption of drug targets. The versatile ready-to-use Caco-2 cell-based plates can also be utilised to simulate drug transport across the blood-brain barrier (BBB), investigate carrier-mediated transport mechanisms, and evaluate drug toxicity.
This pre-plated permeability assay delivers highly reproducible results whilst offering researchers a holistic approach to help determine the oral drug absorption and the bioavailability of drug candidates, as well as toxicity, and transport mechanisms.
Ready-to-use Caco-2 Permeability Cell-based Plates
ReadyCell’s Caco-2 Permeability Cell-based Plates are pre-plated and ready-to-use, providing researchers with a fast, reliable, and versatile tool for the evaluation of intestinal permeability of novel oral drugs during in vitro preclinical studies, enabling the lead optimisation process in drug discovery.
The innovative CacoReady in vitro cell-based model contains 21-day differentiated Caco-2 cells, widely recognized as the gold standard by regulatory authorities, for the evaluation of passive and active transport and the absorption of orally administered drugs. It plays a crucial role in assessing the intestinal permeability of new oral drugs during in vitro preclinical research. Its significance in this field makes it an indispensable tool for drug discovery and development researchers.
Revolutionising In Vitro Drug Permeability Studies
CacoReady, a flexible cell-based model, provides an all-encompassing platform for evaluating drug permeability. Based on a differentiated Caco-2 cell monolayer with morphological and functional properties of the in vivo intestinal barrier, the CacoReady cell-based assay kit is a cell model that closely mimics the structure and function of the human intestinal barrier which regulates the absorption of substances into the body. CacoReady is derived from Caco-2 cells which are a human colorectal carcinoma cell line, ideal for intestinal absorption simulations.
The pre-plated Caco-2 cell-based permeability assay kit eliminates the need for in-house cell line development or cell purchase and propagation, saving researchers valuable time and resources for their permeability or transport experiments. In addition, ReadyCell’s Caco-2 cell plates feature a unique trademarked gel-like substance, which enables cells to be shipped at room temperature whilst maintaining their quality and function, helping researchers achieve optimal results and avoid any errors during the initial handling and storage phase.
CacoReady is a very versatile cell-based model that provides insights into drug absorption dynamics, as well as blood-brain barrier transport, carrier-mediated transport mechanisms, and drug toxicity.
A Versatile and Comprehensive Caco-2 Cell-Based Model
The ready-to-use Caco-2 Permeability assay is a very versatile cell-based model, that can be used for a number of applications including comprehensively assessing drug permeability through passive diffusion and active transport, enabling simulation of active drug transport through the blood-brain barrier (BBB), investigating carrier-mediated transport mechanisms, and evaluating drug toxicity on the Caco-2 cell monolayer.
Drug Permeability Assessment
CacoReady is a versatile cell-based model, offering a comprehensive platform for drug permeability assessment. It enables the evaluation of drug permeability through both passive diffusion and active transport mechanisms. Additionally, this innovative model can assess drug transport across a monolayer of Caco-2 cells, providing invaluable insights into drug absorption dynamics.
Simulating Active Drug Transport through the Blood-Brain Barrier
Researchers using CacoReady can simulate active drug transport through the blood-brain barrier (BBB). The Caco-2 cells in this model form a tight barrier and express MDR1 and BCRP efflux transporters, offering a unique opportunity to gain insights into drug delivery to the central nervous system.
Investigating Drug-Carrier Transport Mechanisms
CacoReady facilitates the investigation of carrier-mediated transport mechanisms involved in drug absorption and transport processes. This allows researchers to explore and understand the intricate details of how drugs interact with carriers during absorption, contributing to a more comprehensive understanding of drug behaviour.
Drug Toxicity Assessment
In addition to its permeability assessment capabilities, the CacoReady cell-based plates can be utilised to evaluate the toxicity of drugs on the Caco-2 cell monolayer. This feature enhances the utility of CacoReady in safety studies, providing a holistic approach to drug development.
Caco-2 Permeability Plates 24-well and 96-well Plate Formats
CacoReady is available in two convenient plate formats: 24-well and 96-well. Cells can be provided on transwells for differentiated and polarised cells or multiwells for just differentiated cells. For the 24-well format, individual transwell units can also be purchased, offering flexibility for specific research needs.
Features & Benefits of the Caco-2 Permeability Cell-based Plates
- Pre-plated with Caco-2 cells
- Versatile cell-based model for a number of applications
- 24-well and 96-well plate formats
- Highly reproducible results
- User-friendly and convenient
- The gold standard method for evaluating absorption of oral drugs
- Adaptable to automation
- Available on demand
- Transported in a patented shipping medium that ensures cell viability even at room temperature
- Learn more about CacoReady
CacoReady Delivery Information
- Manufacturing Time: Manufacturing begins the week after the order is placed and takes 3 weeks to produce.
- Packaging and Preparation: Orders are packaged and prepared for shipment on Monday/Tuesday; a confirmation email is included once the product is sent.
- Delivery Time: Orders are delivered between Wednesday and Thursday.
- Global Reach: Shipment within the EU typically takes 24-48 hours, while outside the EU, delivery typically takes 48-96 hours, ensuring swift global reach for researchers worldwide.
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