A Game-Changer in Predicting Drug-Induced Gastrointestinal Toxicity
CacoReady, a Useful Cell Model to Predict Drug-Induced Gastrointestinal Toxicity
A ReadyCell .pdf Case Study – Author: Marta Olle Monge, Jonatan Cucala and Lourdes Gombau. Department of Research and Development, ReadyCell SL
The CacoReady Cell-Based Assay is Pioneering Early-Stage Indicators in Gastrointestinal Toxicity Assessment
CacoReadyTM and its two early-stage indicators of cell barrier integrity (TEER and LY PF) are a valuable toxicity screening tool that performs more efficiently than the conventional 96-well plastic plate system and the late-stage indicators while providing high-quality toxicity screening data.
The conventional method for evaluating compound intestinal toxicity involves using undifferentiated human colon adenocarcinoma-derived cells (Caco-2) cultured in 96-well microplates. However, this approach limits the assessment to late-stage parameters when evaluating cellular viability.
CacoReadyTM, a ready-to-use Caco-2 cell-based model, emerges as a superior alternative to standard toxicity assays.
Differentiated Caco-2 cells plated on transwell inserts allow evaluating early-stage indicators of cell barrier integrity which could facilitate a better predictive value than conventional tests.
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