HistoSure, in cooperation with Charles River Discovery Research Services Germany, now offers a set of groundbreaking highly validated species-specific antibodies that give researchers the possibility to exploit the full capacity of humanized mouse models.
HistoSure, a product line of Synaptic Systems GmbH, a well-known developer and manufacturer of antibodies, is focused on providing highly evaluated and well-tested antibodies for preclinical and clinical research. One of the research topics on which HistoSure specializes is humanized mice.
Humanized mouse models for the study of human diseases
Humanized mice – immunodeficient mice engrafted with functional human cells – have become increasingly important for the study of human diseases. Although “classical” mouse studies are extremely important to understand basic biological processes, there are limitations to mouse studies when investigating human biology. Especially cancer and cancer immunotherapy research lead to a growing need for faithful mouse models that recapitulate the complexity of human malignancy and immune contexture within the tumor microenvironment.
Human xenograft models, using human cell lines injected into immunodeficient mice, are common models to evaluate cytotoxic therapies in cancer, but do not reflect intra-tumor heterogeneity and should preferably be used in relatively early stages of drug development. PDX models, in which tumor samples obtained from patients are transplanted into immunodeficient mice, better resemble the original tumors in patients and have therefore higher predictive value in drug development studies. Next-generation PDX models are additionally engrafted with human immune cells and are valuable models for immune-based therapies.
Researchers can now exploit the full prospects of PDX research
Histological analysis of humanized mouse models is impeded, as widely used antibodies have often been developed to function in many species and thus do not discriminate between human and mouse components in humanized mouse models. Now HistoSure with the co-operation of Charles River Discovery Research Services Germany GmbH has closed this gap and offers a set of specially developed and highly validated species-specific antibodies that finally give the researchers the possibility to exploit the full prospects of PDX research.
HistoSure strives to offer antibodies against a target molecule as pairs, with one antibody recognizing only the human protein and the other only the murine counterpart, thus providing maximum insight into the complex factors that influence the growth and spread of cancer.
HistoSure antibodies discriminate between murine and human proliferating cells in a humanized mouse spleen: