Fluoroalkylation and Bioconjugation ReagentsDetails
CF Plus Chemicals provides novel reagents for fluoroalkylation and bioconjugation that propel further innovation in drug design, drug discovery and development of advanced materials.
The company’s innovative product range includes fluoroalkyl azides, fluoroalkyl triazoles, protein crosslinkers, difluoromethylation reagents, perfluoroalkoxylation reagents, Togni reagents and many more.
Togni Reagents for Fluoroalkylation and Bioconjugation
CF Plus Chemicals is a pioneer in the development and production of first and second-generation Togni reagents and other products for fluoroalkylation and bioconjugation.
The trademarked fluoroalkylation technology, founded on the patented second generation of Togni reagents, facilitates brand new prospects and opportunities in the development of protein conjugates and the next generations of protein therapeutics.
Second generation Togni reagents
The second generation of patented Togni reagents developed by CF Plus Chemicals is designed to help fluoroalkylation become a commonly utilised tool for the successful modification of a full array of molecular targets. As these advanced compounds can transfer a wide selection of RCF2CF2 fragments, virtually using the same reaction conditions developed for the first-generation of Togni reagents, they constitute an efficient tool for late-stage incorporation of various RCF2CF2 units into molecules of interest.
Whether for small or large molecules, this innovative fluoroalkylation technology could unleash the full potential of therapeutic candidates and advance the bioconjugation of physiologically relevant entities.
In small molecule research, unexplored chemical space avenues may be accessed through novel easy-to-use reagents.
In large molecule research, the CF Plus Chemicals offers solutions that exploit the unique chemical reactivity of Togni reagents to achieve effective and controlled site-selective bioconjugation of peptides, proteins and antibodies.
Fluorinated reagents and building blocks for drug discovery
CF Plus Chemicals produces niche fluorinated reagents and building blocks which can facilitate exciting new ways for researchers and scientists to accelerate drug discovery and improve their understanding of biomolecular interactions.
Fluoroalkyl azides are a versatile chemical speciality that can help create a plethora of previously inaccessible fluoroalkylated heterocycles, which are particularly appealing for the development of new drugs and pesticides.
The unique fluoroalkyl azide kits are perfectly suitable for emerging high-throughput discovery technologies based on combinatorial chemistry, such as DNA-encoded libraries and fragment-based drug discovery (FBDD).
Moreover, fluoroalkyl azides provide an elegant solution for attaching fluorinated probes to alkynylated biomolecules in order to study their structure and interactions by 19F NMR spectroscopy.
Protein characterisation reagents
In the field of proteomics, CF Plus Chemicals has developed a range of MS-proteomic reagents for protein characterisation by surface fingerprinting and by chemical crosslinking.
About CF Plus Chemicals
CF Plus Chemicals is a chemical and biochemical company founded in 2014 as a spin-off of the ETH Zurich university and is headquartered in Brno, Czechia.
Specialising in the development and production of first and second generation Togni reagents and other products for fluoroalkylation and bioconjugation, CF Plus Chemicals, provides powerful solutions for the design of new drugs and bioconjugation of complex biomolecules towards antibody drug conjugates for immuno-oncology.
CF Plus Chemicals has a mission to enable pharma, biotech, medicinal chemistry and academic organizations to leverage the unique properties of fluorinated compounds and help them create innovative cures for devastating human diseases.ProductsThe groundbreaking kit Clickable 19F NMR Probes, developed by CF Plus Chemicals, includes a variety of 9 fluorinated azides that …
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